Department of Statistics

Recent Instructors Zhang, Daowen	ST 520	Statistical Principles of Clinical Trial and Epidemiology
	Course Description This course will introduce some basic statistical concepts and methods used in Epidemiology and will focus on the statistical principles and methods used in clinical trials, including Phase I to IV clinical trials, with emphasis on phase III trials. We will discuss ways of treatment allocation that will ensure valid inference on treatment comparision. Other topics include sample calculation, survival analysis and early stopping of a clinical trial. Course Syllabus Introduction Introcution to Epidemiology Introduction to History of Clinical Trials Phase I and II Clinical Trials Phase III Clinical Trials Randomization Design-based Inference Fixed Allocation Randomization Adaptive Randomization Procedures Response Adaptive Randomization Mechanics of Randomization Additional Phase III clinical trails Blinding and Placebos Ethics Protocol Document Sample Size Calculations Comparing More than Two Treaments Causality, Non-compliance and Intent-to-treat Survival Analysis in Phase III Clinical Trials. Course Prerequisites ST 511 Course Corequisites ST 512 Recent Textbooks None