FITS OF HCV LOAD DATA BY 3-STEP GLS FOR DIFFERENT THETA VALUES Initial fit of model by OLS OLS estimate of beta 1.421831 1.284388 -0.1850593 Estimate of sigma squared 29797148898 Estimate of sigma 172618.5 3-step GLS fit of model with power 0.5 Estimate of beta at 1 iterations 1.419455 1.263665 -0.1822357 Estimate of beta at 2 iterations 1.419546 1.264332 -0.1823144 Estimate of beta at 3 iterations 1.419543 1.264311 -0.1823119 Estimate of beta at 4 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 5 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 6 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 7 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 8 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 9 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 10 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 11 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 12 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 13 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 14 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 15 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 16 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 17 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 18 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 19 iterations 1.419543 1.264312 -0.182312 Estimate of beta at 20 iterations 1.419543 1.264312 -0.182312 Estimate of sigma squared 15913.24 Estimate of sigma 126.1477 3-step GLS fit of model with power 1 Estimate of beta at 1 iterations 1.425236 1.280036 -0.1823489 Estimate of beta at 2 iterations 1.425400 1.280757 -0.1823919 Estimate of beta at 3 iterations 1.425401 1.280730 -0.1823873 Estimate of beta at 4 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 5 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 6 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 7 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 8 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 9 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 10 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 11 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 12 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 13 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 14 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 15 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 16 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 17 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 18 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 19 iterations 1.425401 1.280732 -0.1823875 Estimate of beta at 20 iterations 1.425401 1.280732 -0.1823875 Estimate of sigma squared 0.01070570 Estimate of sigma 0.1034684