Department of Statistics Seminar
North Carolina State University

presents

Jeffrey Thorne

North Carolina State University

"Incorporating Protein Structure into Models of Protein Evolution"

ABSTRACT

An evolutionary model that combines protein structure and evolution is introduced. This hidden Markov model allows likelihood analysis of aligned protein sequences and does not require the underlying structure of these aligned sequences to be known. One component of the model describes the organization of secondary structure and solvent accessibility along a protein sequence and another specifies the evolutionary process for each category of secondary structure and solvent accessibility. Proteins with known structure are used to empirically estimate model parameters representing these two components. The phylogeny, the third and final component of the model, can be estimated from the data set of interest. We evaluate the components of our model with a parametric bootstrap approach. Relevance of the model to prediction of protein secondary structure will also be discussed.

Friday, February 13, 1998

3:35 - 4:35 pm

206 Cox Hall

Refreshments will be served on the second floor of Dabney Hall (left of Room 222) at 3:00 pm.