Department of Statistics Seminar
North Carolina State University

presents

Dr. Roy N. Tamura

Eli Lilly and Company

"Comparing the Time to Response in Anti-depressant Clinical Trials"

ABSTRACT

Current antidepressants have a delayed onset of action and there is considerable interest in developing new products which exhibit a shorter time to response. In this talk, I will outline the medical background of depression, and psychiatric clinical trials. I will introduce the cure model which has been used in oncology clinical trials; this model has some attractive features for the problem of differentiating speed of onset. I will describe some of our own proposed methods involving the cure model which include a Cramer-von Mises type test statistic and a bootstrap procedure, and I will also describe some very recent work done by others which combine logistic regression, and proportional hazards model into the cure model

Friday, January, 19, 2001

3:35 - 4:35 pm

206 Cox Hall

Refreshments will be served on the second floor of Dabney Hall (left of Room 222) at 3:00 pm.