Department of Statistics Seminar
North Carolina State University

presents

Dr. Susan A. Murphy

University of Michigan

"Experimental Methods for Developing Dynamic Treatment Regimes"

ABSTRACT

Dynamic treatment regimes are individually tailored treatments that provide treatment to individuals only when and if they need the treatment and adjust the level of treatment to the individual's need. The experimental development of dynamic treatment regimes provides a paradigm whereby empirical evidence and statistical methods can improve clinical practice in which most treatment is adaptive, particularly in the management of chronic, relapsing disorders such as alcohol and drug addiction, chronic pain and mental illness. In the development and evaluation of a dynamic treatment regime, decision rules for how treatment level and type should vary with time are specified prior to the beginning of treatment; these rules use time varying measurements of subject-specific risk and response to determine treatment level and type. In this talk we propose an experimental paradigm for developing dynamic treatment regimes. We also discuss traditional experimental methods used to construct the decision rules and explicate the implicit scientific assumptions behind the methods

Friday, February, 06, 2004

3:35 - 4:35 pm

206 Cox Hall

Refreshments will be served on the second floor of Dabney Hall (left of Room 222) at 3:00 pm.