presents
Tim Hanson
University of South Carolina
Identifiability of Models for Multiple Diagnostic Testing in the Absence of a Gold Standard
Abstract
We discuss the issue of identifiability of latent-class models for dichotomous
diagnostic tests in the absence of a gold standard. Models are generally posited
in terms of disease prevalences, sensitivities, specificities, and conditional
dependence terms. Goodman's (1974, Biometrika) method is used to check
identifiability via computing packages that allow symbolic matrix compuations
such as Mathematica and Maple, and further developed to find model parameters
that are actually identifiable in an otherwise non-identified model using an
approach due to Rothenberg (1971, Econometrika). The method for dichotomous
tests is then generalized to ordinal and continuous outcomes and applied to
Bayesian semiparametric models for obtaining ROC curves without a gold-standard
when covariates are available. We present illustrations using simulated and
real data.
Friday, 30 September
3:00pm - 4:00pm
2203 SAS Hall