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Course Syllabus

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What is Biostatistics?

About NCSU

About DCRI

Raleigh and Research Triangle

Sister Programs
 

This is the tentative 2009 syllabus -- subject to change.

On most days (Mon-Fri), instruction will be in the form of lectures, special presentations, and group panel discussions in a morning session from 10:00 am - noon. In the afternoon session from 1:30 pm - 3:30pm, students will engage in "hands-on" activities including learning to use statistical software, data analyses, and computer simulation exercises.

Each week will feature a field trip related to issues of importance to biostatistics. Bus transportation will be provided.

Following common statistical practice, students will be randomized into teams of 2-3. During the first week of the program, each team will be assigned a project involving data from a real study carried out by Duke Clinical Research Institute or other research institutions. Over the course of the program, teams will become familiar with the data and, using techniques learned in class, carry out analyses to address the questions from the study. Teams will present their results during the last week of the program.

On weekends, we will take several "fun" field trips to attractions in the Triangle area and beyond. Field trips are given below are representative and are subject to change.


 

Week 1
Sun-6/7   Arrival, registration, and opening dinner and social
Mon-6/8 AM Introduction to SIBS and "How I became interested in statistics:" Personal histories of some SIBS instructors
  PM Randomized trials vs. observational studies
Tue-6/9 AM Clinical Research and the PURSUIT Trial (an example of a large clinical trial, discussed by the lead physician investigator)
  PM Descriptive statistics and probability
Wed-6/10 AM Probability, continued
  PM Introduction to SAS statistical software
Thu-6/11 AM Population, sample, and sampling
  PM Field trip to DCRI (Meet with biostatisticians and clinicians, tour the Duke campus)
Fri-6/12 AM Hypothesis testing, estimation, and confidence intervals
  PM Random sampling on the computer
Sat-6/13 AM/PM Trip to North Carolina Coast, Wrightsville Beach
Week 2
Mon-6/15 AM Hypothesis testing, estimation, and confidence intervals, continued
  PM Using statistical software for hypothesis tests
Tue-6/16 AM Sample size and power
  PM Sample size calculation in practice
Wed-6/17 AM Introduction to clinical trials: Randomization, sample size, conduct of trials, and the intent-to-treat principle
  PM Designing a clinical trial and planning the statistical analysis
Thu-6/18 AM Introduction to clinical trials: Randomization, sample size, conduct of trials, and the intent-to-treat principle, continued
  PM Lab 6 continued: Designing a clinical trial and planning the statistical analysis
Fri-6/19 AM From lab to patient : Statistics in drug development
  PM Field trip to GlaxoSmithKline (Tour, presentations by GSK biostatisticians)
Sat-6/20 AM/PM Durham Bulls Baseball game

 

Week 3
Mon-6/22 AM Associations among variables and introduction to linear regression analysis
  PM Using statistical software for estimating associations and regression analysis
Tue-6/23 AM Introduction to multiple linear regression
  PM Using statistical software for multiple linear regression analysis
Wed-6/24 AM Introduction to logistic regression analysis
  PM Using statistical software for logistic regression analysis
Thu-6/25 AM Preparing for a career in biostatistics - graduate study
  PM Free lab period
Fri-6/26 AM Missing data and noncompliance in clinical trials
  PM Field trip to SAS Institute (tour, presentations by SAS statisticians and developers)
Sat-6/27 AM/PM Trip to Emerald Pointe Water Park (Greensboro)
Week 4
Mon-6/29 AM Genetics and genomics and the role of biostatistics
  PM Genetics and genomics, continued
Tue-6/30 AM Time-to-event data and staggered study entry
  PM Analyzing time-to-event data using statistical software
Wed-7/1 AM Time-to-event data, continued
  PM Analyzing time-to-event data using statistical software
Thu-7/2 AM Regression analysis for time-to-event data -- the proportional hazards (Cox) model
  PM Proportional hazards regression analysis using statistical software
Fri-7/3 AM/PM University closed
Sat-7/4 AM/PM Happy Fourth of July!
Trip to fireworks display at North Carolina State Fairgrounds

 

Week 5
Mon-7/6 AM Research ethics and human subjects protections in clinical trials
  PM Human subjects protections training
Tue-7/7 AM What causes heart disease? Introduction to observational studies and confounding
  PM Observational studies and confounding, continued
Wed-7/8 AM Case study
  PM Biostatistical collaborations at the DCRI
Thu-7/9 AM When should a clinical trial be stopped? An introduction to early stopping and interim monitoring of clinical trials
  PM Presentation skills and Powerpoint
Fri-7/10 AM/PM Field trip to DUMC Adult Diagnostic and Interventional Cardiac Catheterization Lab
Sat - 7/11 AM/PM Trip to NC Zoo
Week 6
Mon-7/13 AM/PM Field trip to the Duke Center for Human Genetics
Tues-7/14 AM/PM No class: Preparation for student team project presentations
Wed-7/15 AM/PM No class: Preparation for student team project presentations
Thu-7/16 AM/PM Student team project presentations, followed by farewell dinner
Fri-7/17 AM Evaluation and wrap-up
  PM Ready to head home!