This is the tentative 2009 syllabus -- subject to change.
On most days (Mon-Fri), instruction will be in the form of lectures, special presentations, and group panel discussions in a morning session from 10:00 am - noon. In the afternoon session from 1:30 pm - 3:30pm, students will engage in "hands-on" activities including learning to use statistical software, data analyses, and computer simulation exercises.
Each week will feature a field trip related to issues of importance to biostatistics. Bus transportation will be provided.
Following common statistical practice, students will be randomized into teams of 2-3. During the first week of the program, each team will be assigned a project involving data from a real study carried out by Duke Clinical Research Institute or other research institutions. Over the course of the program, teams will become familiar with the data and, using techniques learned in class, carry out analyses to address the questions from the study. Teams will present their results during the last week of the program.
On weekends, we will take several "fun" field trips to attractions in the Triangle area and beyond. Field trips are given below are representative and are subject to change.
| Week 1 | ||
| Sun-6/7 | Arrival, registration, and opening dinner and social | |
| Mon-6/8 | AM | Introduction to SIBS and "How I became interested in statistics:" Personal histories of some SIBS instructors |
| PM | Randomized trials vs. observational studies | |
| Tue-6/9 | AM | Clinical Research and the PURSUIT Trial (an example of a large clinical trial, discussed by the lead physician investigator) |
| PM | Descriptive statistics and probability | |
| Wed-6/10 | AM | Probability, continued |
| PM | Introduction to SAS statistical software | |
| Thu-6/11 | AM | Population, sample, and sampling |
| PM | Field trip to DCRI (Meet with biostatisticians and clinicians, tour the Duke campus) | |
| Fri-6/12 | AM | Hypothesis testing, estimation, and confidence intervals |
| PM | Random sampling on the computer | |
| Sat-6/13 | AM/PM | Trip to North Carolina Coast, Wrightsville Beach |
| Week 2 | ||
| Mon-6/15 | AM | Hypothesis testing, estimation, and confidence intervals, continued |
| PM | Using statistical software for hypothesis tests | |
| Tue-6/16 | AM | Sample size and power |
| PM | Sample size calculation in practice | |
| Wed-6/17 | AM | Introduction to clinical trials: Randomization, sample size, conduct of trials, and the intent-to-treat principle |
| PM | Designing a clinical trial and planning the statistical analysis | |
| Thu-6/18 | AM | Introduction to clinical trials: Randomization, sample size, conduct of trials, and the intent-to-treat principle, continued |
| PM | Lab 6 continued: Designing a clinical trial and planning the statistical analysis | |
| Fri-6/19 | AM | From lab to patient : Statistics in drug development |
| PM | Field trip to GlaxoSmithKline (Tour, presentations by GSK biostatisticians) | |
| Sat-6/20 | AM/PM | Durham Bulls Baseball game |
| Week 3 | ||
| Mon-6/22 | AM | Associations among variables and introduction to linear regression analysis |
| PM | Using statistical software for estimating associations and regression analysis | |
| Tue-6/23 | AM | Introduction to multiple linear regression |
| PM | Using statistical software for multiple linear regression analysis | |
| Wed-6/24 | AM | Introduction to logistic regression analysis |
| PM | Using statistical software for logistic regression analysis | |
| Thu-6/25 | AM | Preparing for a career in biostatistics - graduate study |
| PM | Free lab period | |
| Fri-6/26 | AM | Missing data and noncompliance in clinical trials |
| PM | Field trip to SAS Institute (tour, presentations by SAS statisticians and developers) | |
| Sat-6/27 | AM/PM | Trip to Emerald Pointe Water Park (Greensboro) |
| Week 4 | ||
| Mon-6/29 | AM | Genetics and genomics and the role of biostatistics |
| PM | Genetics and genomics, continued | |
| Tue-6/30 | AM | Time-to-event data and staggered study entry |
| PM | Analyzing time-to-event data using statistical software | |
| Wed-7/1 | AM | Time-to-event data, continued |
| PM | Analyzing time-to-event data using statistical software | |
| Thu-7/2 | AM | Regression analysis for time-to-event data -- the proportional hazards (Cox) model |
| PM | Proportional hazards regression analysis using statistical software | |
| Fri-7/3 | AM/PM | University closed |
| Sat-7/4 | AM/PM | Happy Fourth of July! Trip to fireworks display at North Carolina State Fairgrounds |
| Week 5 | ||
| Mon-7/6 | AM | Research ethics and human subjects protections in clinical trials |
| PM | Human subjects protections training | |
| Tue-7/7 | AM | What causes heart disease? Introduction to observational studies and confounding |
| PM | Observational studies and confounding, continued | |
| Wed-7/8 | AM | Case study |
| PM | Biostatistical collaborations at the DCRI | |
| Thu-7/9 | AM | When should a clinical trial be stopped? An introduction to early stopping and interim monitoring of clinical trials |
| PM | Presentation skills and Powerpoint | |
| Fri-7/10 | AM/PM | Field trip to DUMC Adult Diagnostic and Interventional Cardiac Catheterization Lab |
| Sat - 7/11 | AM/PM | Trip to NC Zoo |
| Week 6 | ||
| Mon-7/13 | AM/PM | Field trip to the Duke Center for Human Genetics |
| Tues-7/14 | AM/PM | No class: Preparation for student team project presentations |
| Wed-7/15 | AM/PM | No class: Preparation for student team project presentations |
| Thu-7/16 | AM/PM | Student team project presentations, followed by farewell dinner |
| Fri-7/17 | AM | Evaluation and wrap-up |
| PM | Ready to head home! | |