Course info

Course syllabus

Class notes

Homework assignments and due dates


additional references


Course objective:

This course will focus primarily on the statistical principles and methods used in clinical trials, including phase I to IV clinical trials. Although the class will have emphasis on phase III trials, we will also discuss the feature and statisitcal issues in phase I and II clinical trials. For phase III trials, we will discuss ways of treatment allocation that will ensure valid inference on treatment comparison. Other topics include sample size calculation, survival analysis and early stopping of a clinical trial and noncompliance. We will also discuss some issues on causal inference.

Course Co-requisites

ST 501 or ST 701, Fundamentals of Statistical Inference I or Statistical Theory I Please see the instructor if you have questions about the suitability of your background.

See the class notes for more detailed information